Research done on APS Therapy
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All Rights Reserved.
Different clinical studies in New Zealand, Canada and South Africa show
the significant positive effect of APS Therapy on the sensation of pain
and the mobility of the treated persons.

Research studies were done 751 patients with disorders like
osteoarthritis of the knee, osteoporoses of the lower vertebra,
neurosurgical pain, and chronic pain, different muscle soreness's and
slow healing wounds.

Research proves that 73% of the patients with osteoporoses experience
a positive effect directly after the first treatment. After the second
treatment is number has increased to even 83%. The group of patients
that experience no effect more than two treatments is only 13%. This
shows that APS Therapy has a positive effect on the patient in an early
stage of the treatment.

Some interesting researches can be downloaded from the APS Therapy
Worldwide site. Click here to see the research.
(www.apstherapy.com)

THE SOUTH AFRICAN MEDICAL
RESEARCH COUNCIL (MRC) AND
THE UNIVERSITY OF CAPE TOWN

Head of Project
Prof. A.E. Bunn (Medical Research
Council) Prof. L. Meyers (Head of
the Rheumatic Disease Unit: Faculty
of Medicine University of Cape
Town).

Study
40 Patients with painful patient's
osteoarthritis of the knees were
recruited from a list of patients
requiring total knee replacements.

Method
Double-blinded placebo-controlled
study measuring self-reported pain,
morning stiffness and night pain.

Results
APS Therapy reduces pain, morning
stiffness and night pain to a highly
significant degree (p=0,0003).

Conclusion
Prof. A.E. Bunn: "The fact that the
sample group was chosen from
severe osteoarthritic patients
requiring total knee replacements
makes this result very were
impressive".
Prof.L. Meyers: "This study has
shown that the use of pain relief
pulse (APS) shows that after two (2)
sequential applications significant
reduction of self reported pain is
achieved".

THE UNIVERSITY OF DURBAN
WESTVILLE

Head of Project
Mr. C.A. Liggings (Senior lecturer
and Head of the Department of
Physiotherapy; University of Durban
Westville and King Edward
Hospital.)

Study
10 Patients with a variety of pain
conditions and who had showed
minimal or no response to other
electrotherapeutic modalities were
selected

Method
Patients were treated with APS
Therapy after the treatment with
other modalities. Visual Analogue
Pain Scale (VAPS) was used as
criteria in this study.

Results
40% of the patients required only
one treatment to relieve pain
completely (Numerical Pain Rating
scale = 0-10); 80% of Patients had
minimal pain by the end of two
treatment sessions. (N.P.R.S = 0-2)

Conclusion
Mr. C.A. Liggins: "In the case of
deep seated pain, the APS Therapy
device was more effective than other
modalities".

THE UNIVERSITY OF PRETORIA

Head of Project
Dr. J. du Preez (Senior Consultant,
Department of Neurosurgery;
University of Pretoria and
Consultant; Gauteng Provincial
Administration).

Study
31 Patients suffering neurosurgical
pain conditions and awaiting
destructive surgery were selected.

Method
Clinical experience over a period of
three months.

Results
A significant improvement in certain
surgical conditions.

Conclusion
Dr. J. du Preez: "For the past few
years APS Therapy has been used
with success as an adjunctive to
neurosurgery in different patients,
presenting with both acute but
mostly chronic pain states. We
propose that all patients waiting for
destructive surgery should first be
put on a thorough trial of APS
Therapy".

THE UNIVERSITY OF PRETORIA

Head of Project
JC Seegers, M-L Lottering, AM
Joubert, F Joubert, AM Koorts, CA
Engelbrecht and DH van Papendorp
(Departments of Physiology,
Biochemistry and Physics, University
of Pretoria, South Africa)

Study
The aim of the study was to
investigate the effects of the
application of a small amplitude,
direct current (DC), pulsed electrical
fuel on extracellular and
intra-cellular ATP levels and total
(intracellular and secreted) cAMP
levels in vitro and in vivo systems.

Method
Two APS devices were used,
delivering a periodic, direct current,
pulsed electrical field. The pulsed
frequency used was 150Hz and the
duration of treatment was 8 minutes
for all studies. ATP was determined
with an ATP Bioluminescence assay
kit. cAMP was determined with a
cAMP Enzyme immuno-assay
encephalin system.

Results
Results of ATP levels in vitro showed
that the total concentrations
of ATP (intracellular and
extracellular) was however
significantly higher in the electrically
treated cells. The total cAMP levels
were decreased in cultured HeLa
cells with electrical treatment.
Further results showed the total
cAMP levels were, significantly
increased in isolated lymphocytes
with electrical treatment.
Interestingly, an opposite effect was
seen in the plasma samples (ATP
levels in vivo). In all 9 of the
volunteers a statistically decrease
were seen with electrical treatment.
In all 9 plasma samples, cAMP levels
in vivo were decreased after
electrical treatment.

Conclusion
The clear effects on ATP and cAMP
levels seen in these experiments
indicate that the frequency,
waveform and signal strength of the
applied electrical field, is suitable for
effecting measurable changes in the
body. However the differences in the
nature of these effects seen in the in
vivo and in vitro samples indicate
that the effects are of a complex
nature.

Published
The Medicine Journal,
January/February, 2000



THE UNIVERSITY OF THE FREE
STATE

Head of Project
Prof. C.L. Odendaal (Head of the Pain
Control Unit; Dept. of
Anaesthesiology; Faculty of Medicine;
University of the Free State).

Study
76 Patients with lower back pain due
to osteoporosis, were selected.

Method
Randomised, double-blinded, placebo
controlled study. Visual Analogue Pain
Scale (VAPS) was the method.

Results
APS Therapy relieves pain to a
statistically highly significant degree (p
=0,0001 0,0033)

Conclusion
Prof. C.L. Odendaal: "Clinically the
effect of treatment was very
successful. APS treatment may be an
effective treatment for chronic
backache in the osteoporotic patient.

Published
The South African Journal of
Anaesthesiology and Analgesia, March,
1999.

THE UNIVERSITY OF
WITWATERSRAND,
JOHANNESBURG

Head of Project
Ms. P. Berger Physio (Wits), L. Matzer
Msc M(University of Pretoria)

Study
Placebo controlled study on 99
patients with osteo arthritis (OA) of
the knee to investigate the
effectiveness of APS.

Method
Randomised single blind study. Visual
Analogue Pain Scale was used. Knee
flexion by goniometer.

Results
It was statistically proved that APS
Therapy is effective in a treatment of
patients with osteoarthritis in the
knee.

Conclusion
The increased improvement in flexion
in the APS group is remarkable
considering that the treatment has
ceased, yet, ongoing changes were
occurring. The increased flexibility of
the patients in the APS group enables
the patient to participate more easily
in an exercise regimen…and assists in
the improvement of the quality of life
of the osteo-arthirits patient" Ms. P.
Berger.

Published
The South African Journal of
Anaesthesiology and Analgesia, June,
1999.


THE UNIVERSITY OF PRETORIA

Head of Project
Prof. D.H. van Papendorp (MBChB,
PhD Med, Univ of Stellenbosch)

Study
Assessment of Pain Relief on 285
patients with chronic pain.

Method
Visual Analogue Pain Scale (VAPS)
Mobility Index.

Results
The mean VAPS and MI improved
significantly in the patient group as a
whole.

Conclusion
Both on clinical grounds and by
patient self assessment, APS Therapy
appeared to be most beneficial. This
study has also demonstrated
significant clinical efficacy of the APS
Device" Prof van Papendorp

Published
The Medicine Journal,
January/February, 2000

THE UNIVERSITY OF PRETORIA

Head of Project
Prof. D.H. van Papendorp M.C Maritz
and N Dippenaar (department of
Physiology, University of Pretoria,
South Africa)

Study
The aim of this pilot study was to
investigate what effects APS Therapy
has on 2 endogenous opioids viz
endorphin, and leu-encelphalin, and
on the nonopioid neuropeptide,
Substance P.

Results
Beta endorphin concentrations
showed a fourfold increase in the pain
group while the control
group showed a 60% increase. Plasma
leucine encephaline concentrations
increased with APS therapy in the pain
group. APS treatment had no effect on
absorbance readings of the control
group. Interestingly though, the
absorbance readings of the pain group
increased slightly after APS therapy,
approaching those of the control
group.

Conclusion
The specific reason for the progressive
increase in leucine encephalin
concentrations with APS therapy in the
pain group, is attributed to the
presently unknown effect of electrical
currents of specific quality and
duration on the b sulting in artificially
increased levels of substances
resulting in attenuation of pain for pain
relief. Combined with the increase in
plasma endorphin concentrations
demonstrated in this study, leucine
encephalin may be internally involved
in restructuring the relieve of chronic
pain in humans.

Published
Medicine Journal, January/February,
2002; 44(1); 36-40


STUDIES CONDUCTED

New Zealand
Head of Project
Dr. P. James Watt, Auckland,
New Zealand

Study
32 patients treated for a wide
range of musculoskeletal pain
conditions, using the VAPS.

Results
78% reported a positive response
to the first treatment. Of the 24
need patients that received a
follow-up treatment, 83%
reported a positive response.

Conclusion
"Generally the treatment was
used in conjunction with
mobilization of manipulation and
was a useful addendum. The
efficacy was generally similar to
acupuncture used in the same
situation but was easier to
administer and on occasions had
very successful relief of pain… "I
found the device easy to use and
particularly useful in reducing the
initial discomfort mobilization.
This resulted in a reduced need
for pharmaceutical prescription"
Dr. Watt


Head of Project
Dr. P. Botes, Auckland, New
Zealand

Study
38 patients treated for a wide
range of musco-skeletal pain
conditions and to determine the
impact of the APS device on
wound healing and mobility,
using the VAPS

Results
After the first treatments, the
average VAPS score fell 40%.
After the second treatments, the
average VAPS score fell 38%.
Both changes in VAPS scores
were significant, with p < 0.0001
for the corresponding t-tests. 3
Participants presented with
slow-healing wounds, all of which
reported accelerated rates of
healing (in addition to reduced
discomfort).

Conclusion
The efficiency was generally
good, especially for conditions
relating to the lumbar/sacroiliac
region. In addition to pain relief,
the device appeared to have a
noticeable effect on mobility.
Those who presented with
slow-healing wounds experienced
dramatically accelerated rates of
healing. There was also a reduced
need for pharmaceutical
prescription" Dr. Botes.


South Africa
Head of Project
Prof. C.J. Zeelie (Unit for Health
Services, Port Elizabeth
Technikon)

Study
In this project the ability of
electro-medicine, and in
particular a device known as APS
Compact, to relieve pain of 243
patients was investigated.
Individuals were treated for a
variety of pains encountered in
various body parts including both
hard and soft tissue.

Results
In all cases good pain relief was
observed. In some cases the
extent of pain relief was not very
great, but the relief experienced
was so significantly profound that
the individual who had not been
able to sleep for several days
actually fell asleep during the
treatment.

Conclusion
The APS Compact was found to
be extremely effective in the
treatment of a wide variety of
pains, in both soft and hard
tissues of the body. In a wide
spectrum of health or medical
disorders the device was found to
be useful in the treatment of pain
in both young and old, sick and
healthy individuals. Good
accumulative and surprising
residual effects were observed in
the treatment of pain in terminally
ill patients. The APS Compact is a
good, inexpensive alternative for
conventional medicine.

Canada
Head of Project
Dr. C. Marais, Saskatchewan,
Canada

Study
174 patients treated for 55
different ailments over 3 months
period.

Results
From the 157 patients treated (17
did not return for follow-up
treatments), the following
observations were made:
• 72% improved or felt that APS
therapy was better than other
treatment modalities
• 28% did not improve or felt that
APS therapy was equal to other
modalities
• 50% had immediate relief of
pain
• 20% had immediate
improvement of swelling.
• 54% had immediate
improvement of stiffness.
• 50% had immediate
improvement of mobility.
• 23% had gradual improvement
of pain.
• 8% had a gradual improvement
of swelling.
• 15% had gradual improvement
of stiffness.
• 14% had gradual improvement
of mobility.


"...but the relief
experienced was so
significantly profound
that the individual
who had not been
able to sleep for
several days actually
fell asleep during the
treatment."
Prof. C.J. Zeelie